Occlusal stimuli influence on the expression of IGF-1 and the IGF-1 receptor in the rat periodontal ligament

被引：0
|
作者：
Termsuknirandorn, Saewadee [1 ]
Hosomichi, Jun [1 ]
Soma, Kunimichi [1 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch, Div Oral Hlth Sci, Dept Orofacial Dev & Funct,Bunkyo Ku, Tokyo 1138549, Japan
来源：
ANGLE ORTHODONTIST | 2008年 / 78卷 / 04期
关键词：
periodontal ligament; occlusal stimuli; IGIF-1; IGF-1; receptor; cell proliferation;
D O I：
10.2319/0003-3219(2008)078[0610:OSIOTE]2.0.CO;2
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective: To test the hypothesis that hypofunction/recovered occlusal function has no effect on the changes in insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expressions and cell proliferation of periodontal ligament (PDL) cells. Materials and Methods: To produce occlusal hypofunction, the appliances were attached to the rats' maxillary and mandibular incisors. Subsequently, occlusal contact of the molar area was thoroughly recovered by removal of the appliances. Results: In periodontal sections, localization of IGF-1, the IGF-1 receptor, and proliferating cell nuclear antigen (PCNA) immunoreactive cells was significantly more expressed in the control group compared with the hypofunctional group (P <.01). In addition, after the recovery of the occlusion, IGF-1, IGF-1 receptor, and PCNA were detected significantly much more than in the hypofunction group (P <.01). Conclusion: The hypothesis was rejected. This study suggests that occlusal stimuli induce cell proliferation of PDL cells by increasing IGF-1 and IGF-1 receptor expression.
引用
收藏
页码：610 / 616
页数：7
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