Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations

被引：69

作者：

Sun, Xianfeng ^{[1
]}

Zhou, Le ^{[2
]}

Li, Wei ^{[1
]}

Zhang, Xumu ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol & Pharmaceut Chem, Piscataway, NJ 08854 USA

[2] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 03期

关键词：

D O I：

10.1021/jo702068w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C-3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantio selective synthesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.

引用

页码：1143 / 1146

页数：4

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