GSK2967901A, a novel small molecule SIRT1 activator for the topical treatment of psoriasis

被引:0
|
作者
Ellis, J. [1 ]
Seefeld, M. [1 ]
Miller, W. [1 ]
Fox, R. [1 ]
Evans, K. [1 ]
Atkins, C. [1 ]
Dai, H. [1 ]
Jayawickreme, C. [1 ]
Bedard, M. [1 ]
Santos, L. [1 ]
Gupta, A. [1 ]
Grillot, D. [2 ]
Nicodeme, E. [2 ]
Weiss, M. [1 ]
机构
[1] GSK, Collegeville, PA USA
[2] GSK, Les Ulis, France
关键词
D O I
10.1016/j.jid.2017.07.065
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
LB985
引用
收藏
页码:B10 / B10
页数:1
相关论文
共 50 条
  • [21] Emerging roles of SIRT1 activator, SRT2104, in disease treatment
    Chang, Ning
    Li, Junyang
    Lin, Sufen
    Zhang, Jinfeng
    Zeng, Weiqiang
    Ma, Guoda
    Wang, Yajun
    SCIENTIFIC REPORTS, 2024, 14 (01)
  • [22] Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator
    Zeng, Zhenhua
    Chen, Zhongqing
    Xu, Siqi
    Song, Rui
    Yang, Hong
    Zhao, Ke-seng
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 2015
  • [23] TEM1657 is a new small molecule for the topical and oral treatment of psoriasis
    Ginglinger, J.
    Hannewald, P.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (09) : B19 - B19
  • [24] TEM1657 is a new small molecule for the oral and topical treatment of psoriasis
    Ginglinger, J. -F.
    Hannewald, P.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019, 33 : 44 - 44
  • [25] SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
    Blum, Charles A.
    Ellis, James L.
    Loh, Christine
    Ng, Pui Yee
    Perni, Robert B.
    Stein, Ross L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (02) : 417 - 432
  • [26] A novel small-molecule activator of Lyn kinase for the treatment of type 1 diabetes
    Huang, H.
    Wang, Q.
    Buteau, J.
    DIABETOLOGIA, 2024, 67 : S127 - S127
  • [27] Treatment with a Sirt1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice
    Kuno, Atsushi
    Hori, Yusuke
    Sato, Tatsuya
    Kouzu, Hidemichi
    Tanno, Masaya
    Miki, Takayuki
    Horio, Yoshiyuki
    Miura, Tetsuji
    JOURNAL OF CARDIAC FAILURE, 2011, 17 (09) : S149 - S149
  • [28] SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
    Dai, Han
    Kustigian, Lauren
    Carney, David
    Case, April
    Considine, Thomas
    Hubbard, Basil P.
    Perni, Robert B.
    Riera, Thomas V.
    Szczepankiewicz, Bruce
    Vlasuk, George P.
    Stein, Ross L.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (43) : 32695 - 32703
  • [29] Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer’s disease
    Jesus Campagna
    Sujyoti Chandra
    Bruce Teter
    Whitaker Cohn
    Johnny Pham
    Young-Sug Kim
    Barbara Jagodzinska
    Kanagasabai Vadivel
    Parvez Alam
    Tina Bilousova
    Malaney Young
    Chris Elias
    Juan Marcucci
    Ilinca Flacau
    Ainsley Jackman
    Samar Padder
    Dongwook Wi
    Chunni Zhu
    Patricia Spilman
    Michael E Jung
    Dale E Bredesen
    Varghese John
    Scientific Reports, 15 (1)
  • [30] Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration
    Yasushi Kitaoka
    Kana Sase
    Chihiro Tsukahara
    Naoki Fujita
    Naoto Tokuda
    Jiro Kogo
    Hitoshi Takagi
    Japanese Journal of Ophthalmology, 2020, 64 : 298 - 303