Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

被引：104
|
作者：
Segal, BH
Barnhart, LA
Anderson, VL
Walsh, TJ
Malech, HL
Holland, SM
机构：
[1] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
[2] Roswell Pk Canc Inst, Dept Med, Div Infect Dis, Buffalo, NY 14263 USA
[3] Roswell Pk Canc Inst, Dept Immunol, Div Infect Dis, Buffalo, NY 14263 USA
[4] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA
[5] NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 11期
关键词：
D O I：
10.1086/430068
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections ( 7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.
引用
收藏
页码：1684 / 1688
页数：5
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