Hypoxia:: the tumor's gateway to progression along the angiogenic pathway

被引：110
|
作者：
Brahimi-Horn, C [1 ]
Berra, E [1 ]
Pouysségur, J [1 ]
机构：
[1] Ctr Antoine Lacassagne, CNRS UMR 6543, Inst Signaling Dev Biol & Canc Res, F-06189 Nice, France
来源：
TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期
关键词：
D O I：
10.1016/S0962-8924(01)82185-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1 alpha (HIF-1 alpha) has been elucidated, as has the mechanism by which stabilization of HIF-1 alpha leads to initiation of the transcription of target genes involved in growth of blood vessels.
引用
收藏
页码：S32 / S36
页数：5
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