Hypoxia:: the tumor's gateway to progression along the angiogenic pathway

被引：110
|
作者：
Brahimi-Horn, C [1 ]
Berra, E [1 ]
Pouysségur, J [1 ]
机构：
[1] Ctr Antoine Lacassagne, CNRS UMR 6543, Inst Signaling Dev Biol & Canc Res, F-06189 Nice, France
来源：
TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期
关键词：
D O I：
10.1016/S0962-8924(01)82185-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1 alpha (HIF-1 alpha) has been elucidated, as has the mechanism by which stabilization of HIF-1 alpha leads to initiation of the transcription of target genes involved in growth of blood vessels.
引用
收藏
页码：S32 / S36
页数：5
相关论文
共 50 条
  • [1] The hypoxia-inducible factor and tumor progression along the angiogenic pathway
    Brahimi-Horn, MC
    Pouysségur, J
    INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL. 242, 2005, 242 : 157 - 213
  • [2] Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study
    Kyzas, PA
    Stefanou, D
    Batistatou, A
    Agnantis, NJ
    CANCER LETTERS, 2005, 225 (02) : 297 - 304
  • [3] Potentiated action on the progression of OSMF by hypoxia mediated signaling pathway by the epithelial mesenchymal transition and angiogenic apparatus
    Gupta, Sanjana
    Shetty, Devi Charan
    Gulati, Nikita
    Juneja, Saurabh
    Jain, Anshi
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2023, 19 (SUPPL 1) : S389 - S396
  • [4] Angiogenic signaling aberrantly induced by tumor hypoxia
    Takenaga, Keizo
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 : 31 - 48
  • [5] Hypoxia, metabolism, and tumor progression
    Simon, Marie Celeste
    MOLECULAR CANCER RESEARCH, 2016, 14
  • [6] Hypoxia, metabolism, and tumor progression
    Simon, M. Celeste
    CANCER RESEARCH, 2016, 76
  • [7] Hypoxia, metabolism, and tumor progression
    Simon, M. Celeste
    CANCER RESEARCH, 2012, 72
  • [8] Tumor hypoxia and cancer progression
    Zhou, Jie
    Schmid, Tobias
    Schnitzer, Steffen
    Bruene, Bernhard
    CANCER LETTERS, 2006, 237 (01) : 10 - 21
  • [9] HIFs, hypoxia, and tumor progression
    Simon, M. Celesta
    CANCER RESEARCH, 2013, 73
  • [10] HIFs, hypoxia, and tumor progression
    Simon, C.
    EUROPEAN JOURNAL OF CANCER, 2013, 49 : S80 - S80
12345