Eating disorders are severe mental illnesses that are challenging to treat and often follow a chronic course. They are associated with immense impairment on the psychological, physical, interpersonal, and social level as well as significant direct and indirect cost. Therefore, prevention and early intervention are of utmost importance. Based on a qualitative literature review, we summarized the empirical evidence for the efficacy of universal and selective prevention of eating disorders. Programs available in German and/or English were included in the review. In addition to research on efficacy and effectiveness, the areas of implementation, dissemination, and reach were identified as key issues for future studies. Furthermore, more research is needed on the relationship of cost, benefit, and risks of eating disorder prevention.