Inhibition of nitric oxide production in RAW 264.7 macrophages by diterpenoids from Phellinus pini

被引：28
|
作者：
Jang, Hyun Jin [1 ]
Yang, Ki-Sook [1 ]
机构：
[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 06期
关键词：
8,14-labdadien-13-ol; Dehydroabietic acid; Phellinus pini; LPS-activated RAW 264.7 cells; SUBMERGED MYCELIAL CULTURE; CUNNINGHAMIA-KONISHII; DEHYDROABIETIC ACID; ANTIBACTERIAL; MANOOL;
D O I：
10.1007/s12272-011-0608-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
8,14-labdadien-13-ol (1) and dehydroabietic acid (2) were isolated from the fruit body of Phellinus pini. Elucidation of their structures was based on spectroscopic methods including IR, MS, and NMR (1D and 2D). Two compounds were screened for their ability to inhibit NO production in LPS-activated RAW 264.7 cells. Compounds 1 and 2 at 30 mu M and 50 mu M, respectively, inhibited NO production in activated macrophages.
引用
收藏
页码：913 / 917
页数：5
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