Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders-A Review

被引:232
|
作者
Sokola-Wysoczanska, Ewa [1 ]
Wysoczanski, Tomasz [2 ]
Wagner, Jolanta [2 ,3 ]
Czyz, Katarzyna [4 ]
Bodkowski, Robert [4 ]
Lochynski, Stanislaw [3 ,5 ]
Patkowska-Sokola, Bozena [4 ]
机构
[1] Lumina Cordis Fdn, Szymanowskiego St 2-A, PL-51609 Wroclaw, Poland
[2] FLC Pharma Ltd, Wroclaw Technol Pk,Muchoborska St 18, PL-54424 Wroclaw, Poland
[3] Univ Technol, Fac Chem, Dept Bioorgan Chem, Wybrzeze Wyspianskiego St 27, PL-50370 Wroclaw, Poland
[4] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Inst Anim Breeding, Chelmonskiego St 38c, PL-50001 Wroclaw, Poland
[5] Wroclaw Coll Physiotherapy, Inst Cosmetol, Kosciuszki 4 St, PL-50038 Wroclaw, Poland
关键词
cardiovascular system; omega-3 fatty acids; alpha-linoleic acid (ALA); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); lipids; nutrition; ALPHA-LINOLENIC ACID; PERCUTANEOUS CORONARY INTERVENTION; LONG-CHAIN OMEGA-3-FATTY-ACIDS; DUAL ANTIPLATELET THERAPY; FISH-OIL; MYOCARDIAL-INFARCTION; DOCOSAHEXAENOIC ACID; DOUBLE-BLIND; HEART-DISEASE; ATRIAL-FIBRILLATION;
D O I
10.3390/nu10101561
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Cardiovascular diseases are described as the leading cause of morbidity and mortality in modern societies. Therefore, the importance of cardiovascular diseases prevention is widely reflected in the increasing number of reports on the topic among the key scientific research efforts of the recent period. The importance of essential fatty acids (EFAs) has been recognized in the fields of cardiac science and cardiac medicine, with the significant effects of various fatty acids having been confirmed by experimental studies. Polyunsaturated fatty acids are considered to be important versatile mediators for improving and maintaining human health over the entire lifespan, however, only the cardiac effect has been extensively documented. Recently, it has been shown that omega-3 fatty acids may play a beneficial role in several human pathologies, such as obesity and diabetes mellitus type 2, and are also associated with a reduced incidence of stroke and atherosclerosis, and decreased incidence of cardiovascular diseases. A reasonable diet and wise supplementation of omega-3 EFAs are essential in the prevention and treatment of cardiovascular diseases prevention and treatment.
引用
收藏
页数:21
相关论文
共 50 条
  • [1] Polyunsaturated fatty acids and their potential therapeutic role in multiple sclerosis
    Mehta, Lahar R.
    Dworkin, Robert H.
    Schwid, Steven R.
    NATURE CLINICAL PRACTICE NEUROLOGY, 2009, 5 (02): : 82 - 92
  • [2] Polyunsaturated fatty acids and their potential therapeutic role in multiple sclerosis
    Lahar R Mehta
    Robert H Dworkin
    Steven R Schwid
    Nature Clinical Practice Neurology, 2009, 5 : 82 - 92
  • [3] ω-3 polyunsaturated fatty acids and the cardiovascular system
    Kryzhanovskii S.A.
    Vititnova M.B.
    Human Physiology, 2009, 35 (4) : 491 - 501
  • [4] Polyunsaturated Fatty Acids and Inflammation: Therapeutic Potential in Rheumatoid Arthritis
    Calder, Philip C.
    CURRENT RHEUMATOLOGY REVIEWS, 2009, 5 (04) : 214 - 225
  • [5] Polyunsaturated Fatty Acids Therapeutic Potential for Long QT Syndrome
    de la Cruz, Alicia
    Perez, Marta E.
    Rainer, Quinn C.
    Larsson, H. P.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 331A - 331A
  • [6] Fatty acids and their therapeutic potential in neurological disorders
    Lei, Enie
    Vacy, Kristina
    Boon, Wah Chin
    NEUROCHEMISTRY INTERNATIONAL, 2016, 95 : 75 - 84
  • [8] Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?
    Bozzatello, Paola
    Rocca, Paola
    Mantelli, Emanuela
    Bellino, Silvio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (21)
  • [9] n-3 Polyunsaturated fatty acids and the cardiovascular system
    Angerer, P
    von Schacky, C
    CURRENT OPINION IN LIPIDOLOGY, 2000, 11 (01) : 57 - 63
  • [10] Polyunsaturated fatty acids and cardiovascular disease
    Richard, Doriane
    Bausero, Pedro
    Schneider, Charlotte
    Visioli, Francesco
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (20) : 3277 - 3288