The role of growth factors in central nervous system tumours

被引：0
|
作者：
Nieder, C
Schlegel, J
Andratschke, N
Thamm, R
Grosu, AL
Molls, M
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Radiat Oncol, D-81675 Munich, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Pathol, D-81675 Munich, Germany
[3] Univ Texas, MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA
来源：
ANTICANCER RESEARCH | 2003年 / 23卷 / 2C期
关键词：
brain tumours; glioma; meningioma; growth factors; radiotherapy; prognostic factors; glioblastoma multiforme;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of growth factors in tumour growth and progression has increasing been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGE TGF-beta, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.
引用
收藏
页码：1681 / 1686
页数：6
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