Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein-Barr virus

被引：24
|
作者：
Katzman, RB [1 ]
Longnecker, R [1 ]
机构：
[1] Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
来源：
JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷
关键词：
D O I：
10.1099/vir.0.19252-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Epstein-Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-beta-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.
引用
收藏
页码：2987 / 2992
页数：6
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