Platelets as targets of snake venom metalloproteinases

被引：78
|
作者：
Kamiguti, AS [1 ]
机构：
[1] Univ Liverpool, Dept Haematol, Liverpool L69 3GA, Merseyside, England
来源：
TOXICON | 2005年 / 45卷 / 08期
关键词：
haemorrhage; snake venom metalloproteinases; platelet function; collagen receptors; alpha(2)beta(1) integrin;
D O I：
10.1016/j.toxicon.2005.02.026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
For centuries snake venoms have been known to interfere with haemostasis and this is now known basically due either to toxins activating/inhibiting clotting factors, having effects on blood vessels or interfering with platelet function. In this short review, the interaction of one major group of toxins, the snake venom metalloproteinases, with platelets is considered. This is relevant for understanding the mechanism of haemorrhage induced by these toxins. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1041 / 1049
页数：9
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