Miniature non-contact photoacoustic probe based on fiber-optic photoacoustic remote sensing microscopy

被引：13
|
作者：
Zhou, Jiasheng [1 ]
Zhou, Jingying [1 ]
Wang, Wei [2 ]
Liang, Siqi [1 ]
Jing, Lili [2 ]
Bo, Shou-Hang [1 ,3 ]
Chen, Sung-Liang [1 ,4 ,5 ]
机构：
[1] Shanghai Jiao Tong Univ, Univ Michigan Shanghai Jiao Tong Univ Joint Inst, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Engn Res Ctr Cell & Therapeut Antibody, Sch Pharm, Minist Educ, Shanghai 200240, Peoples R China
[3] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
[4] Minist Educ, Engn Res Ctr Digital Med & Clin Translat, Shanghai 200030, Peoples R China
[5] Shanghai Jiao Tong Univ, State Key Lab Adv Opt Commun Syst & Networks, Shanghai 200240, Peoples R China
来源：
OPTICS LETTERS | 2021年 / 46卷 / 22期
基金：
中国国家自然科学基金;
关键词：
LABEL-FREE; TOMOGRAPHY;
D O I：
10.1364/OL.444889
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Photoacoustic (PA) remote sensing (PARS) microscopy, featured by non-contact operation, has shown great potential for PA microscopy (PAM) imaging applications. However, current PARS microscopy systems are mainly based on free-space light, making the imaging head bulky and inconvenient to use. These issues hinder selected applications such as PA endoscopy and handheld PAM. Here, we report a miniature probe capable of non-contact PAM based on PARS microscopy. By utilizing fiber-optic components including a wavelength division multiplexer and an optical circulator, the imaging head can be highly miniaturized with a diameter of similar to 3.0 mm. Also, since all light is transmitted via fibers, the fiber-optic PARS microscopy system is relatively easy to build and facilitates scanning of the probe. In vivo imaging of a zebrafish larva and imaging of lithium metal batteries are conducted using the probe, showing its good imaging capability. (C) 2021 Optica Publishing Group
引用
收藏
页码：5767 / 5770
页数：4
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