Phenolic constituents and anticancer properties of Morus alba (white mulberry) leaves

被引：58
|
作者：
Chan, Eric Wei Chiang [1 ]
Wong, Siu Kuin [2 ]
Tangah, Joseph [3 ]
Inoue, Tomomi [4 ]
Chan, Hung Tuck [5 ]
机构：
[1] UCSI Univ, Fac Appl Sci, Kuala Lumpur 56000, Malaysia
[2] Xiamen Univ Malaysia, Sch Fdn Studies, Sepang 43900, Selangor, Malaysia
[3] Sabah Forestry Dept, Forest Res Ctr, Sandakan 90009, Sabah, Malaysia
[4] Natl Inst Environm Studies NIES, Ctr Environm Biol & Ecosyst Studies, Tsukuba, Ibaraki 3050053, Japan
[5] Univ Ryukyus, Secretariat Int Soc Mangrove Ecosyst ISME, Fac Agr, Okinawa 9030129, Japan
来源：
JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2020年 / 18卷 / 03期
关键词：
Flavonoids; Benzofurans; Cytotoxic; Moracins; Morachalcones; Chalcomoracin; BIOACTIVE BENZOFURAN DERIVATIVES; HUMAN BREAST-CANCER; NF-KAPPA-B; ANTIOXIDANT ACTIVITY; L; LEAVES; INHIBITORY CONSTITUENTS; FLAVONOL GLYCOSIDES; HUMAN COLON; CELL-DEATH; APOPTOSIS;
D O I：
10.1016/j.joim.2020.02.006
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylquinic acids (phenolic acids) and morachalcones (chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were PubMed, PubMed Central, ScienceDirect, Google, Google Scholar, J-Stage, PubChem and China National Knowledge Infrastructure. (C) 2020 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：189 / 195
页数：7
相关论文
共 50 条
  • [41] Chemical Constituents of Morus alba
    Chen, C. Y.
    Kao, C. L.
    Yeh, H. C.
    Song, P. L.
    Lin, R. J.
    Li, H. T.
    CHEMISTRY OF NATURAL COMPOUNDS, 2020, 56 (05) : 904 - 905
  • [42] Chemical Constituents of Morus alba
    C. Y. Chen
    C. L. Kao
    H. C. Yeh
    P. L. Song
    R. J. Lin
    H. T. Li
    Chemistry of Natural Compounds, 2020, 56 : 904 - 905
  • [43] (Poly)phenolic fingerprint and chemometric analysis of white (Morus alba L.) and black (Morus nigra L.) mulberry leaves by using a non-targeted UHPLC-MS approach
    Sanchez-Salcedo, Eva Ma.
    Tassotti, Michele
    Del Rio, Daniele
    Hernandez, Francisca
    Jose Martinez, Juan
    Mena, Pedro
    FOOD CHEMISTRY, 2016, 212 : 250 - 255
  • [44] Morphological and pomological characteristics of white mulberry (Morus alba L.) accessions
    Hashemi, Sogand
    Khadivi, Ali
    SCIENTIA HORTICULTURAE, 2020, 259
  • [45] Effects of Dietary Mulberry Leaves (Morus alba L.) on Egg Yolk Color
    Lokaewmanee, Kanda
    Mompanuon, Sawitree
    Khumpeerawat, Panuwat
    Yamauchi, Koh-en
    JOURNAL OF POULTRY SCIENCE, 2009, 46 (02): : 112 - 115
  • [46] Isolation of flavonoids from mulberry (Morus alba L.) leaves with macroporous resins
    Wang, Jun
    Wu, Fu An
    Zhao, Hui
    Liu, Li
    Wu, Qiu Sheng
    AFRICAN JOURNAL OF BIOTECHNOLOGY, 2008, 7 (13): : 2147 - 2155
  • [47] The impact of spacing on growth, yield and moisture retention capacity of leaves in mulberry, Morus alba
    Ananya, N. C.
    Vijayendra, M.
    Swathi, H. C.
    Chandrashekar, S.
    Gowda, Manjunath
    Naika, Ramakrishna
    BIOSCIENCE BIOTECHNOLOGY RESEARCH COMMUNICATIONS, 2015, 8 (01): : 20 - 24
  • [48] Preparation and Evaluation of Herbal Tea and Toothpaste of Mulberry Leaves (Morus alba L.)
    Rivai, Harrizul
    Rina, W.
    Rina, D. Y.
    Ramdani
    Fatimah, S.
    Asiska, P. D.
    Akmal, D.
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (04): : 1672 - 1677
  • [49] Research on some factors affecting extraction of chlorophyll from mulberry leaves (Morus alba)
    Tran, Q. H.
    Pham, T. Q.
    Vu, H. T.
    Le, D. X.
    Tran, O. T.
    Ngo, A. Q.
    Nguyen, T. D.
    Hoang, B. T.
    Do, S. T.
    3RD INTERNATIONAL CONFERENCE ON NEW MATERIAL AND CHEMICAL INDUSTRY, 2019, 479
  • [50] Isolation and viscometric characterization of hydrocolloids from mulberry (Morus alba L.) leaves
    Lin, Hsiang-Yun
    Lai, Lih-Shiuh
    FOOD HYDROCOLLOIDS, 2009, 23 (03) : 840 - 848
12345