Evaluation of the rat airway epithelial RL65 cell line as a novel in-vitro model for screening inhaled drug candidates

被引：0
|
作者：
Hutter, V. [1 ]
Tang, N. [1 ]
Zann, V. [2 ]
Cooper, A. [2 ]
Pritchard, D. I. [3 ]
Bosquillon, C. [1 ]
机构：
[1] Univ Nottingham, Sch Pharm, Div Adv Drug Delivery & Tissue Engn, Nottingham NG7 2RD, England
[2] AstraZeneca R&D Charnwood, Loughborough, Leics, England
[3] Univ Nottingham, Sch Pharm, Div Mol & Cellular Sci, Nottingham NG7 2RD, England
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 2010年 / 62卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1230 / 1232
页数：3
相关论文
共 50 条
  • [41] Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o–: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies
    Carsten Ehrhardt
    Carsten Kneuer
    Jennifer Fiegel
    Justin Hanes
    Ulrich Schaefer
    Kwang-Jin Kim
    Claus-Michael Lehr
    Cell and Tissue Research, 2002, 308 : 391 - 400
  • [42] High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
    O'Brien, P. J.
    Irwin, W.
    Diaz, D.
    Howard-Cofield, E.
    Krejsa, C. M.
    Slaughter, M. R.
    Gao, B.
    Kaludercic, N.
    Angeline, A.
    Bernardi, P.
    Brain, P.
    Hougham, C.
    ARCHIVES OF TOXICOLOGY, 2006, 80 (09) : 580 - 604
  • [43] High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
    P. J. O’Brien
    W. Irwin
    D. Diaz
    E. Howard-Cofield
    C. M. Krejsa
    M. R. Slaughter
    B. Gao
    N. Kaludercic
    A. Angeline
    P. Bernardi
    P. Brain
    C. Hougham
    Archives of Toxicology, 2006, 80 : 580 - 604
  • [44] Bovine caruncular epithelial cell line (BCEC-1) serves as in vitro model for drug transportation by multidrug-resistance gene product P-GP
    Waterkotte, B.
    Doering, B.
    Hambruch, N.
    Baal, N.
    Artoni, L.
    Geyer, J.
    Tinneberg, H. -R
    Pfarrer, C.
    PLACENTA, 2008, 29 (08) : A67 - A67
  • [45] TOXI 50-Evaluation of hyaluronic acid-based ocular viscosurgical devices (OVDs) using an in vitro human corneal epithelial cell line model
    Cobb, Jessica
    Lee, Alexandra
    Roger Tran-Son-Tay
    Sarntinoranont, Malisa
    Luu, Hoan-My D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [46] Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion - Initial validation studies
    Wang, Yanfeng
    Zuo, Zhong
    Lee, Kenneth K. H.
    Chow, Moses S. S.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 334 (1-2) : 27 - 34
  • [47] TRANSFORMING GROWTH-FACTOR-ALPHA (TGF-ALPHA) ENHANCES ALVEOLAR EPITHELIAL TYPE-II CELL REPAIR IN A NOVEL IN-VITRO MODEL OF WOUND-HEALING
    KHERADMAND, F
    FOLKESSON, HG
    MATTHAY, MA
    CLINICAL RESEARCH, 1994, 42 (01): : A32 - A32
  • [48] Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
    Ozgur, Burak
    Saaby, Lasse
    Janfelt, Christian
    Langthaler, Kristine
    Eneberg, Elin
    Jacobsen, Anne-Marie
    Badolo, Lassina
    Montanari, Dino
    Brodin, Birger
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021, 169 : 211 - 219
  • [49] The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1-Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line
    Bendas, Sebastian
    Koch, Eugen Viktor
    Nehlsen, Kristina
    May, Tobias
    Dietzel, Andreas
    Reichl, Stephan
    PHARMACEUTICS, 2023, 15 (09)
  • [50] The novel use of the human nasal epithelial cell line RPMI 2650 as an in vitro model to study the influence of allergens and cytokines on transforming growth factor-β gene expression and protein release
    Salib, RJ
    Lau, LC
    Howarth, PH
    CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (06): : 811 - 819
12345