LC3-associated endocytosis and the functions of Rubicon and ATG16L1

被引：25
|
作者：
Magne, Joelle [1 ]
Green, Douglas R. [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源：
SCIENCE ADVANCES | 2022年 / 8卷 / 43期
关键词：
AUTOPHAGY; COMPLEX; LINKS; IDENTIFICATION; PHAGOCYTOSIS; CONJUGATION; ACTIVATION; INHIBITION; MATURATION; REGULATOR;
D O I：
10.1126/sciadv.abo5600
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway. LANDO was initially discovered in a murine model of Alzheimer's disease as a critical regulator of amyloid-I) receptor recycling in microglial cells, playing a protective role against neuronal loss and memory impairment. Recent evidence suggests an emerging role of LANDO in cytokine receptor signaling and innate immunity. Here, we discuss the regulation of two crucial effectors of LANDO, Rubicon and ATG16L1, and their impact on endocytosis, autophagy, and phagocytosis.
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页数：11
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