Synthesis of novel analogues of (+)-varitriol via olefin cross-metathesis reaction

被引:40
|
作者
Nagarapu, Lingaiah [1 ]
Paparaju, Venkateswarlu [1 ]
Satyender, Apuri [1 ]
机构
[1] Indian Inst Chem Technol, Div Organ Chem 2, Hyderabad 500607, Andhra Pradesh, India
关键词
varitriol; analogues; cross-metathesis reaction; Grubb's catalyst; cytotoxicity;
D O I
10.1016/j.bmcl.2008.02.062
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Novel analogues of (+)-varitriol have been synthesized via olefin cross-metathesis reaction using Grubb's catalyst. Newly synthesized compounds were screened for cytotoxicity and they showed mild activity against RAW264.7 and HT29 cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2351 / 2354
页数:4
相关论文
共 50 条
  • [21] Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis
    Chen, Junyi
    Kamitakahara, Hiroshi
    Edgar, Kevin J.
    CARBOHYDRATE POLYMERS, 2020, 229
  • [22] Olefin cross-metathesis reactions and their applications to organic synthesis
    Guo, YC
    Xiao, WJ
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2005, 25 (11) : 1334 - 1341
  • [23] Synthesis of the glycosphingolipid β-galactosyl ceramide and analogues via olefin cross metathesis
    Rai, AN
    Basu, A
    JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (20): : 8228 - 8230
  • [24] Designing liquid-crystalline gold nanoparticles via the olefin cross-metathesis reaction
    Thanh Tung Nguyen
    Thi Le Anh Nguyen
    Deschenaux, Robert
    JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2016, 20 (8-11) : 1060 - 1064
  • [25] Synthesis of (E)-3′-Phosphonoalkenyl Modified Nucleoside Phosphonates via a Highly Stereoselective Olefin Cross-Metathesis Reaction
    Huang, Qiuya
    Herdewijn, Piet
    JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (10): : 3742 - 3753
  • [26] Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis
    Wozniak, Lukasz
    Rajkiewicz, Adam A.
    Monsigny, Louis
    Kajetanowicz, Anna
    Grela, Karol
    ORGANIC LETTERS, 2020, 22 (13) : 4970 - 4973
  • [27] An expedient route to substituted furans via olefin cross-metathesis
    Donohoe, Timothy J.
    Bower, John F.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (08) : 3373 - 3376
  • [28] New approaches to olefin cross-metathesis
    Blackwell, HE
    O'Leary, DJ
    Chatterjee, AK
    Washenfelder, RA
    Bussmann, DA
    Grubbs, RH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (01) : 58 - 71
  • [29] Recent developments in olefin cross-metathesis
    Connon, SJ
    Blechert, S
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (17) : 1900 - 1923
  • [30] New Approaches to Olefin Cross-Metathesis
    1600, American Chemical Society (122):