Role of Ancillary Techniques in Biliary Cytopathology Specimens

被引：7
|
作者：
Layfield, Lester [1 ]
机构：
[1] Univ Missouri, Dept Pathol & Anat Sci, One Hosp Dr,M263 Med Sci Bldg, Columbia, MO 65212 USA
来源：
ACTA CYTOLOGICA | 2020年 / 64卷 / 1-2期
关键词：
Sensitivity; Ancillary testing; Brushings; Cytology; Bile duct; Pancreatic duct; IN-SITU HYBRIDIZATION; PRIMARY SCLEROSING CHOLANGITIS; K-RAS MUTATIONS; BRUSH CYTOLOGY; PANCREATICOBILIARY BRUSHINGS; MESOTHELIN EXPRESSION; PAPANICOLAOU SOCIETY; PROGNOSTIC-FACTOR; DIAGNOSTIC YIELD; BILE;
D O I：
10.1159/000498976
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Biliary brushing cytology has become the standard of practice for the investigation of strictures of the biliary and pancreatic duct systems. The methodology however has a limitation in that it has low diagnostic sensitivity when only cytologic evaluation is used. A number of testing methodologies have been applied to brushing specimens in an attempt to improve overall sensitivity without loss of specificity. These have included DNA ploidy analysis, immunocytochemistry, individual gene mutational analysis, fluorescence in-situ hybridization (FISH), and next generation sequencing (NGS). Currently, FISH coupled with routine cytology appears to be the method of choice for improving diagnostic sensitivity. NGS shows significant promise for improvement of diagnostic sensitivity.
引用
收藏
页码：175 / 181
页数：7
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