The effect of polysialic acid on molecular dynamics of model membranes studied by 31P NMR spectroscopy

被引：12
|
作者：
Timoszyk, A
Gdaniec, Z
Latanowicz, L
机构：
[1] Univ Zielona Gora, Dept Biophys, Inst Biotechnol & Environm Sci, PL-65561 Zielona Gora, Poland
[2] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland
来源：
SOLID STATE NUCLEAR MAGNETIC RESONANCE | 2004年 / 25卷 / 1-3期
关键词：
polysialic acid; phosphatidylcholine bilayer; multilamellar liposomes; molecular dynamics; P-31-NMR;
D O I：
10.1016/j.ssnmr.2003.03.023
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The paper reports the results of our study on the dynamics of model phospholipid membranes studied by P-31 NMR spectroscopy. The P-31 NMR spectra of multilamellar vesicles in temperatures below the main phase transition of PC are reported. The P-31 NMR spectra revealed changes caused by an increase of the membrane fluidity when polysialic acid (polySia) was applied as a modifying agent. The presence of polySia in the external environment of the phospholipid vesicles changes the motional freedom in the region of phosphate group of lipids. Increase of polysialic acid concentration changes structural properties of a membrane by increasing its fluidity. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：142 / 145
页数：4
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