Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase

被引：7

作者：

Kitazawa, Takatoshi

Fukushima, Atsuhito

Okugawa, Shu

Yanagimoto, Shintaro

Tsukada, Kunihisa

Tatsuno, Keita

Koike, Kazuhiko

Kimura, Satoshi

Kishimoto, Toshio

Shibasaki, Yoshikazu

Ota, Yasuo

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Infect Dis, Bunkyo Ku, Tokyo 1138655, Japan

[2] Natl Inst Infect Dis, Dept Virol 1, Lab Rickettsia & Chlamydia, Tokyo, Japan

[3] Univ Tokyo, RCAST, Lab Syst Biol & Med, Tokyo, Japan

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 12-13期

关键词：

chlamydophilal antigens; foam cell formation; c-Jun NH2 terminal kinase; Toll-like receptor 2;

D O I：

10.1016/j.micinf.2007.07.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydophila pneumoniae is known to be associated with atherosclerosis. Recent studies have reported that components of Chlamydophila pneumoniae (chlamydophilal antigens) induce foam cell formation in macrophages. However, the mechanism of foam cell formation induced by chlamyclophilal antigens has yet to be elucidated. In this paper, we first found that mitogen-activated protein kinases including extracellular signal-regulated kinase, p38 and c-Jun NH2 terminal kinase are phosphorylated after stimulation by chlamydophilal antigens. We then showed that chlamydophilal antigens induce foam cell formation mainly via c-Jun NH2 terminal kinase. Finally, we demonstrated that foam cell formation and phosphorylation of mitogen-activated protein kinases induced by chlamydophilal antigens are mainly recognized through Toll-like receptor 2. These results collectively indicated that chlamydophilal antigens induce foam cell formation mainly via Toll-like receptor 2 and c-Jun NH2 teminal kinase. (c) 2007 Published by Elsevier Masson SAS.

引用

页码：1410 / 1414

页数：5

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