Thiosemicarbazone-derived copper(II), cobalt(II) and nickel(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies

被引：23
|
作者：
Sobiesiak, M. [1 ]
Cieslak, M. [2 ]
Krolewska, K. [2 ]
Kazmierczak-Baranska, J. [2 ]
Pasternak, B. [3 ]
Budzisz, E. [4 ]
机构：
[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Pharm, Dept Inorgan & Analyt Chem, Jurasza 2, PL-85089 Bydgoszcz, Poland
[2] Polish Acad Sci, Ctr Mol & Macromol Studies, H Sienkiewicza 112, PL-90363 Lodz, Poland
[3] Univ Lodz, Fac Chem, Lab Mol Spect, Narutowicza 68, PL-90136 Lodz, Poland
[4] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, Muszynskiego 1, PL-90151 Lodz, Poland
来源：
NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 11期
关键词：
TRANSITION-METAL-COMPLEXES; PYRAZOLE BASED LIGANDS; BIOLOGICAL-ACTIVITY; IN-VITRO; N(4)-SUBSTITUTED THIOSEMICARBAZONES; NAPHTHAQUINONE THIOSEMICARBAZONE; ANTIAMEBIC ACTIVITY; CRYSTAL-STRUCTURE; CANCER-CELLS; DERIVATIVES;
D O I：
10.1039/c6nj02899c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper(II), cobalt(II) and nickel (II) complexes (1-6) of 1-[amino(thioxo)methyl]-5-hydroxy-3-methyl-1H-pyrazole have been synthesized and characterized by IR, UV-Vis, NMR, ESI-MS and elemental analysis. Ligand and metal(II) complexes have been screened for their toxic effect on HeLa and K562 cancer cell lines, as well as on normal HUVEC cells. Cytotoxic effectiveness of copper(II) complexes (1 and 4) (IC50 2-5 mu M after 48 h) was 4-50 times higher than that of other complexes and cisplatin. These complexes were non-toxic to primary human endothelial cells. For these complexes, induction of cell apoptosis by the caspase 3/7 assay has been measured. The interactions with DNA by the enzymatic method have also been investigated.
引用
收藏
页码：9761 / 9767
页数：7
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