Two cyclopeptides from the seeds of Annona cherimola

被引：24

作者：

Wélé, A ^{[1
]}

Zhang, YJ

Brouard, JP

Pousset, JL

Bodo, B

机构：

[1] Univ Cheikh Anta Diop Dakar Fann, Fac Med & Pharm, Lab Chim Organ & Therapeut, Dakar, Senegal

[2] Museum Natl Hist Nat, CNRS, ESA 8041, Lab Chim Substances Nat, F-75005 Paris, France

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 19期

关键词：

Annona cherimola; Annonaceae; cyclopeptide; cherimolacyclopeptide E; cherimolacyclopeptide F;

D O I：

10.1016/j.phytochem.2005.06.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided fractionation of cytotoxic of methanol extract of the seeds of Annona cherimola provided two novel cyclic peptides, cherimolacyclopeptide E (1) and cherimolacyclopeptide F (2), which exhibited significant cytotoxic activity against the KB (human nasopharyngeal carcinoma) cell culture system. The peptide 1 and 2 were elucidated by MS/MS fragmentation experiments using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR analyses and chemical degradation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2376 / 2380

页数：5

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