Two cyclopeptides from the seeds of Annona cherimola

被引：24
|
作者：
Wélé, A [1 ]
Zhang, YJ
Brouard, JP
Pousset, JL
Bodo, B
机构：
[1] Univ Cheikh Anta Diop Dakar Fann, Fac Med & Pharm, Lab Chim Organ & Therapeut, Dakar, Senegal
[2] Museum Natl Hist Nat, CNRS, ESA 8041, Lab Chim Substances Nat, F-75005 Paris, France
来源：
PHYTOCHEMISTRY | 2005年 / 66卷 / 19期
关键词：
Annona cherimola; Annonaceae; cyclopeptide; cherimolacyclopeptide E; cherimolacyclopeptide F;
D O I：
10.1016/j.phytochem.2005.06.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioassay-guided fractionation of cytotoxic of methanol extract of the seeds of Annona cherimola provided two novel cyclic peptides, cherimolacyclopeptide E (1) and cherimolacyclopeptide F (2), which exhibited significant cytotoxic activity against the KB (human nasopharyngeal carcinoma) cell culture system. The peptide 1 and 2 were elucidated by MS/MS fragmentation experiments using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR analyses and chemical degradation. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2376 / 2380
页数：5
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