Large Noncoding RNAs Are Promising Regulators in Embryonic Stem Cells

被引：13

作者：

Li, Ya-Pu ^{[1
]}

Wang, Yangming ^{[1
]}

机构：

[1] Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, Beijing 100871, Peoples R China

来源：

JOURNAL OF GENETICS AND GENOMICS | 2015年 / 42卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Embryonic stem cells; Induced pluripotent stem cells; Large noncoding RNAs; Self-renewal; Differentiation; SELF-RENEWAL; LINEAGE COMMITMENT; CIRCULAR RNAS; TRIPLE-HELIX; HUMAN GENOME; XIST RNA; PLURIPOTENCY; DIFFERENTIATION; CHROMATIN; GENES;

D O I：

10.1016/j.jgg.2015.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic stem cells (ESCs) hold great promises for treating and studying numerous devastating diseases. The molecular basis of their potential is not completely understood. Large noncoding RNAs (lncRNAs) are an important class of gene regulators that play essential roles in a variety of physiologic and pathologic processes. Dozens of lncRNAs are now identified to control ESC self-renewal and differentiation. Research on lncRNAs may provide novel insights into manipulating the cell fate or reprogramming somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the recent research efforts in identifying functional lncRNAs and understanding how they act in ESCs, and discuss various future directions of this field.

引用

页码：99 / 105

页数：7

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