Comparative evaluation of vibrational circular dichroism and optical rotation for determination of enantiomeric purity

被引：10

作者：

Zhao, CX ^{[1
]}

Polavarapu, PL ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

来源：

APPLIED SPECTROSCOPY | 2001年 / 55卷 / 07期

关键词：

enantiomeric purity; optical rotation; vibrational circular dichroism; infrared absorption; enantiomeric excess;

D O I：

10.1366/0003702011952721

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Vibrational circular dichroism (VCD) is used to determine enantiomeric purity (EP) of three sample groups, and the results are compared with those obtained from optical rotation. In most typical cases EP determination from optical rotation is more accurate than that from VCD. However, in cases where either optical rotation is very small or different chiral samples are present as a mixture, EP determination from VCD provides definite advantages with reasonable accuracy.

引用

页码：913 / 918

页数：6

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