Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms

被引：2
|
作者：
Frapwell, C. J. [1 ,2 ]
Skipp, P. J. [1 ,3 ,4 ]
Howlin, R. P. [1 ,3 ]
Angus, E. M. [5 ]
Hu, Y. [6 ,7 ]
Coates, A. R. M. [6 ,7 ]
Allan, R. N. [1 ,2 ]
Webb, J. S. [1 ,2 ,3 ]
机构：
[1] Univ Southampton, Fac Environm & Life Sci, Sch Biol Sci, Southampton, Hants, England
[2] Univ Southampton, Natl Biofilms Innovat Ctr, Southampton, Hants, England
[3] Univ Southampton, Inst Life Sci, Southampton, Hants, England
[4] Univ Southampton, Inst Life Sci, Ctr Prote Res, Southampton, Hants, England
[5] Southampton Gen Hosp, Biomed Imaging Unit, Southampton, Hants, England
[6] St Georges Univ London, Inst Infect & Immun, London, England
[7] Helperby Therapeut Grp Plc, London, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 05期
基金：
英国生物技术与生命科学研究理事会;
关键词：
HT61; Staphylococcus aureus; antibiotics; biofilms; proteomics; IN-VITRO; DAPTOMYCIN; PATHOGENESIS; ANTIBIOTICS; VANCOMYCIN; REVEALS;
D O I：
10.1128/AAC.02073-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy
    Abouelhassan, Yasmeen
    Garrison, Aaron T.
    Burch, Gena M.
    Wong, Wilson
    Norwood, Verrill M.
    Huigens, Robert W., III
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (21) : 5076 - 5080
  • [42] Antimicrobial photodynamic therapy effectiveness against susceptible and methicillin-resistant Staphylococcus aureus biofilms
    de Souza Teixeira, Camilo Geraldo
    Sanita, Paula Volpato
    Dias Ribeiro, Ana Paula
    Dias, Luana Mendonca
    Jorge, Janaina Habib
    Pavarina, Ana Claudia
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2020, 30
  • [43] The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin
    Yuechen Hu
    Lili Ouyang
    Duoyun Li
    Xiangbin Deng
    Hongbo Xu
    Zhijian Yu
    Yeqing Fang
    Jinxin Zheng
    Zhong Chen
    Haigang Zhang
    BMC Microbiology, 23
  • [44] The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin
    Hu, Yuechen
    Ouyang, Lili
    Li, Duoyun
    Deng, Xiangbin
    Xu, Hongbo
    Yu, Zhijian
    Fang, Yeqing
    Zheng, Jinxin
    Chen, Zhong
    Zhang, Haigang
    BMC MICROBIOLOGY, 2023, 23 (01)
  • [45] Antimicrobial activity of short lipopeptides against clinical strains of Staphylococcus aureus
    Dawgul, Malgorzata
    Baranska-Rybak, Wioletta
    Greber, Katarzyna
    Guzik, Lukasz
    Nowicki, Roman
    Lukasiak, Jerzy
    Kamysz, Wojciech
    ALERGIA ASTMA IMMUNOLOGIA, 2011, 16 (01): : 31 - 36
  • [46] Antimicrobial Activity of Geranium Oil against Clinical Strains of Staphylococcus aureus
    Bigos, Monika
    Wasiela, Malgorzata
    Kalemba, Danuta
    Sienkiewicz, Monika
    MOLECULES, 2012, 17 (09): : 10276 - 10291
  • [47] Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus
    Moojen, Dirk Jan F.
    Everts, Peter A. M.
    Schure, Rose-Minke
    Overdevest, Ed P.
    van Zundert, Andre
    Knape, Johannes T. A.
    Castelein, Rene M.
    Creemers, Laura B.
    Dhert, Wouter J. A.
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2008, 26 (03) : 404 - 410
  • [48] Antimicrobial activity of disinfectants against different strains of staphylococcus aureus.
    Mattos, TR
    Groppo, FC
    Motta, RHL
    Ramacciato, JC
    Flório, FM
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : 268 - 268
  • [49] Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus
    Britton, S.
    Lee, K.
    Azizova, L.
    Shaw, G.
    Ayre, W. Nishio
    Mansell, J. P.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [50] Antimicrobial activity of gentamicin palmitate against high concentrations of Staphylococcus aureus
    Kittinger, Clemens
    Marth, Egon
    Windhager, Reinhard
    Weinberg, Annelie M.
    Zarfel, Gernot
    Baumert, Rita
    Felisch, Susanne
    Kuehn, Klaus-Dieter
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2011, 22 (06) : 1447 - 1453
12345