Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms

被引：2
|
作者：
Frapwell, C. J. [1 ,2 ]
Skipp, P. J. [1 ,3 ,4 ]
Howlin, R. P. [1 ,3 ]
Angus, E. M. [5 ]
Hu, Y. [6 ,7 ]
Coates, A. R. M. [6 ,7 ]
Allan, R. N. [1 ,2 ]
Webb, J. S. [1 ,2 ,3 ]
机构：
[1] Univ Southampton, Fac Environm & Life Sci, Sch Biol Sci, Southampton, Hants, England
[2] Univ Southampton, Natl Biofilms Innovat Ctr, Southampton, Hants, England
[3] Univ Southampton, Inst Life Sci, Southampton, Hants, England
[4] Univ Southampton, Inst Life Sci, Ctr Prote Res, Southampton, Hants, England
[5] Southampton Gen Hosp, Biomed Imaging Unit, Southampton, Hants, England
[6] St Georges Univ London, Inst Infect & Immun, London, England
[7] Helperby Therapeut Grp Plc, London, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 05期
基金：
英国生物技术与生命科学研究理事会;
关键词：
HT61; Staphylococcus aureus; antibiotics; biofilms; proteomics; IN-VITRO; DAPTOMYCIN; PATHOGENESIS; ANTIBIOTICS; VANCOMYCIN; REVEALS;
D O I：
10.1128/AAC.02073-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
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页数：6
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