Role of serotonin (5-HT)1B receptors in psychostimulant addiction

被引：0
|
作者：
Miszkiel, Joanna [1 ]
Filip, Malgorzata [1 ]
Przegalinski, Edmund [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, Lab Drug Addict Pharmacol, PL-31343 Krakow, Poland
来源：
PHARMACOLOGICAL REPORTS | 2011年 / 63卷 / 06期
关键词：
5-HTIB receptors; psychostimulants; behavioral models of drug addiction; VENTRAL TEGMENTAL AREA; COCAINE-SEEKING BEHAVIOR; 5-HT1B MESSENGER-RNA; NUCLEUS-ACCUMBENS; RAT-BRAIN; EXTRACELLULAR DOPAMINE; BINDING-SITES; D-AMPHETAMINE; RU; 24969; LIGANDS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Psychostimulant (cocaine, amphetamine and its derivatives) addiction is an important health problem with implications in social and economic life. Although mesocorticolimbic dopamine system plays a crucial role in the mechanism responsible for the rewarding effects of these drugs, recent data also show involvement of the brain serotonin (5-HT) system. In the present review we discuss the role of 5-HTIB receptors in the psychostimulant addiction on the base of the effects of 5-HTIB receptor ligands on the behavioral effects of the psychostimulants in experimental models (sensitization, intracranial self-stimulation, conditioned place preference, self-administration and extinction/reinstatement model) used to assess their addictive properties. Moreover, the effect of long-term treatment with psychostimulants on 5-HTIB receptors is also discussed.
引用
收藏
页码：1310 / 1315
页数：6
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