A Turn-On Fluorescent Sensor for Glutathione Based on Bovine Serum Albumin-Stabilized Gold Nanoclusters

被引：14
|
作者：
Qiu, Yan [1 ,2 ,3 ]
Huang, Jianlin [1 ,2 ]
Jia, Li [1 ,2 ]
机构：
[1] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Hubei, Peoples R China
[2] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China
[3] China Natl Geol Ctr Bldg Mat Ind, Yunnan Branch, Kunming 650118, Yunnan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY | 2018年 / 2018卷
关键词：
SELECTIVE DETECTION;
D O I：
10.1155/2018/1979684
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A fluorescence sensor for the detection of glutathione based on the fluorescence recovering of the bovine serum albumin-stabilized gold nanoclusters is reported. This study indicates that glutathione restores the copper-ion-quenched fluorescence by coordinating the bound copper ion in the bovine serum albumin molecule used for stabilizing the gold nanocluster through its sulfydryl. Under the experimental conditions, the fluorescence response showed a linear relationship with the concentration of glutathione over the range from 10 mu M to 400 mu M. The fluorescence sensor successfully detected glutathione in commercial drug products.
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页数：5
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