Integrated bioinformatics analysis for novel miRNAs markers and ceRNA network in diabetic retinopathy

被引：1
|
作者：
Li, Jingru [1 ]
Li, Chaozhong [2 ]
Zhao, Yulan [3 ]
Wu, Xinyu [1 ]
Yu, Shuai [1 ]
Sun, Guihu [1 ]
Ding, Peng [1 ]
Lu, Si [1 ]
Zhang, Lijiao [1 ]
Yang, Ping [1 ]
Peng, Yunzhu [1 ]
Fu, Jingyun [4 ]
Wang, Luqiao [1 ]
机构：
[1] Kunming Med Univ, Dept Cardiol, Affiliated Hosp 1, Kunming, Peoples R China
[2] Kunming Med Univ, Dept Emergency, Affiliated Hosp 1, Kunming, Peoples R China
[3] Kunming Med Univ, Dept Lab Anim Sci, Kunming, Peoples R China
[4] Kunming Med Univ, Dept Endocrinol, Affiliated Hosp 1, Kunming, Peoples R China
来源：
FRONTIERS IN GENETICS | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
diabetic retinopathy; biomarker; microarray; bioinformatics analysis; RNA regulatory pathways; MITOCHONDRIAL RIBOSOMAL-PROTEINS; CLIP-SEQ; DATABASE; GENES; BIOMARKERS; STARBASE; HEART; MRPS;
D O I：
10.3389/fgene.2022.874885
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In order to seek a more outstanding diagnosis and treatment of diabetic retinopathy (DR), we predicted the miRNA biomarkers of DR and explored the pathological mechanism of DR through bioinformatics analysis. Method: Based on public omics data and databases, we investigated ncRNA (non-coding RNA) functions based on the ceRNA hypothesis. Result: Among differentially expressed miRNAs (DE-miRNAs), hsa-miR-1179, -4797-3p and -665 may be diagnosis biomarkers of DR. Functional enrichment analysis revealed differentially expressed mRNAs (DE-mRNAs) enriched in mitochondrial transport, cellular respiration and energy derivation. 18 tissue/organ-specific expressed genes, 10 hub genes and gene cluster modules were identified. The ceRNA networks lncRNA FBXL19-AS1/miR-378f/MRPL39 and lncRNA UBL7-AS1/miR-378f/MRPL39 might be potential RNA regulatory pathways in DR. Conclusion: Differentially expressed hsa-miR-1179, -4797-3p and -665 can be used as powerful markers for DR diagnosis, and the ceRNA network: lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 may represent an important regulatory role in DR progression.
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页数：16
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