Propargylamine Synthesis by Copper-Catalyzed Oxidative Coupling of Alkynes and Tertiary Amine N-Oxides

被引：36

作者：

Xu, Zhanwei ^{[1
]}

Yu, Xiaoqiang ^{[1
]}

Feng, Xiujuan ^{[1
]}

Bao, Ming ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 16期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; 3-COMPONENT SYNTHESIS; TERMINAL ALKYNES; BONDS ADJACENT; EFFICIENT; ALKYNYLATION; ALDEHYDE; DERIVATIVES; ADDITIONS; SALTS;

D O I：

10.1021/jo201059h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for synthesizing N,N-di-methylpropargylamines is described. The synthesis exploited the Cu(II)-catalyzed oxidative alkynylation reaction of tri-methylamine N-oxides with alkynes in the absence of external oxidant. Both aromatic and aliphatic allcynes were utilized to achieve the corresponding products in moderate to excellent yields. The reaction conditions tolerated ester, hydroxy, and aldehyde groups.

引用

页码：6901 / 6905

页数：5

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