Reigning in regulatory T-cell function

被引:1
|
作者
Konopacki, Catherine [1 ,2 ]
Plitas, George [1 ,2 ,3 ]
Rudensky, Alexander [1 ,2 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, Program Immunol, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Surg, Breast Canc Serv, New York, NY 10021 USA
关键词
TGF-BETA; DIFFERENTIATION; TGF-BETA-1; CANCER; GROWTH;
D O I
10.1038/nbt.3285
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
An approach to inhibit the immune-suppressive function of regulatory T cells is demonstrated in a model of graft-versus-host disease.
引用
收藏
页码:718 / 719
页数:2
相关论文
共 50 条
  • [21] Novel molecular mechanisms modulating regulatory T-cell function
    Coffer, P. J.
    IMMUNOLOGY, 2014, 143 : 6 - 6
  • [22] T-CELL REGULATION OF T-CELL FUNCTION
    LEE, SC
    LUCAS, ZJ
    FEDERATION PROCEEDINGS, 1975, 34 (03) : 1030 - 1030
  • [23] Expanding role of T-Cell costimulators in regulatory T-Cell function: Recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells
    Ndhlovu, LC
    Takeda, I
    Sugamura, K
    Ishii, N
    CRITICAL REVIEWS IN IMMUNOLOGY, 2004, 24 (04) : 251 - 266
  • [24] Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma
    Bruneau, Julie
    Canioni, Danielle
    Renand, Amedee
    Marafioti, Teresa
    Paterson, Jennifer C.
    Martin-Garcia, Nadine
    Gaulard, Philippe
    Delfau, Marie-Helene
    Hermine, Olivier
    Macintyre, Elizabeth
    Brousse, Nicole
    Asnafi, Vahid
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (02): : 570 - 574
  • [25] Regulatory T-cell function - When suppressor cells can't suppress
    Fazekas de St Groth, Barbara
    IMMUNOLOGY AND CELL BIOLOGY, 2007, 85 (03): : 179 - 181
  • [26] The Endocannabinoid Anandamide Neither Impairs In Vitro T-Cell Function Nor Induces Regulatory T-Cell Generation
    Lissoni, Paolo
    Tintori, Andrea
    Fumagalli, Luca
    Brivio, Fernando
    Messina, Giuseppina
    Parolini, Daniela
    Biondi, Andrea
    Balestra, Anna
    D'Amico, Giovanna
    ANTICANCER RESEARCH, 2008, 28 (6A) : 3743 - 3748
  • [27] Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy
    Canavan, James B.
    Afzali, Behdad
    Lord, Graham M.
    Lombardi, Giovanna
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2013, 13 (01) : 5 - 7
  • [28] Regulatory T-cell heterogeneity
    Ward-Hartstonge, Kirsten A.
    Vasanthakumar, Ajithkumar
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2018, 7 (03):
  • [29] T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors
    Hu, Jiemiao
    Sun, Chuang
    Bernatchez, Chantale
    Xia, Xueqing
    Hwu, Patrick
    Dotti, Gianpietro
    Li, Shulin
    CLINICAL CANCER RESEARCH, 2018, 24 (12) : 2920 - 2934
  • [30] Ambient air pollution impairs regulatory T-cell function in asthma
    Nadeau, Kari
    McDonald-Hyman, Cameron
    Noth, Elizabeth M.
    Pratt, Boriana
    Hammond, S. Katharine
    Balmes, John
    Tager, Ira
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (04) : 845 - U280