Voltammetric determination of bisoprolol fumarate in pharmaceutical formulations and urine using single-wall carbon nanotubes modified glassy carbon electrode

The electrochemistry of bisoprolol fumarate (BF) has been investigated by differential pulse voltammetry at a single-wall carbon nanotubes (SWNTs) modified glassy carbon electrode (GCE). The prepared electrode showed an excellent electrocatalytic activity towards the oxidation of BE leading to a marked improvement in sensitivity as compared to bare glassy carbon electrode where electrochemical activity for the analyte cannot be observed. The SWNTs-modified GCE exhibited a sharp anodic peak at a potential of similar to 950 mV for the oxidation of BE Under optimum conditions linear calibration curve was obtained over the BF concentration range 0.01-0.1 mM in 0.5 M phosphate buffer solution (pH 7.2) with a correlation coefficient of 0.9789 and detection limit of 8.27 x 10(-7) M. The modified electrode has been applied for the drug determination in human urine with no prior extraction and in commercial tablets. The proposed method has also been validated. (c) 2007 Elsevier Ltd. All rights reserved.