Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats

被引：14

作者：

Ferreira-Machado, Samara Cristina ^{[1
,2
,3
]}

Rocha, Nazareth De Novaes ^{[5
]}

Mencalha, Andre Luiz ^{[3
]}

Barbosa De Melo, Luiz Dione ^{[4
]}

Salata, Camila ^{[2
]}

Ribeiro, Andreia Fortes ^{[2
]}

Torres, Thiago Da Silva ^{[6
]}

Mandarim-De-Lacerda, Carlos Alberto ^{[6
]}

Canary, Paulo Cesar ^{[7
]}

De Freitas Peregrino, Antonio Augusto ^{[2
]}

Goncalves Magalhaes, Luis Alexandre ^{[2
]}

Cabral-Neto, Januario Bispo ^{[3
]}

Dealmeida, Carlos Eduardo ^{[2
]}

机构：

[1] Univ Fed Fluminense, Dept Biol Geral GBG, Lab Radiobiol & Radiomet, BR-24020140 Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Dept Biofis & Biomet, Lab Ciencias Radiol, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, CCS, Lab Controle Expressao Genica, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil

[4] Univ Fed Fluminense, Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, Genet Mol Lab, BR-24020140 Niteroi, RJ, Brazil

[5] Univ Fed Fluminense, Dept Fisiol & Farmacol, BR-24020140 Niteroi, RJ, Brazil

[6] Univ Fed Rio de Janeiro, Inst Biol, Lab Morfomet & Morfol Cardiovasc, Rio De Janeiro, Brazil

[7] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Serv Radioterapia, Fac Med,Dept Radiol, BR-21941 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2010年 / 86卷 / 10期

关键词：

GROWTH-FACTOR-BETA; INDUCED HEART-DISEASE; LOCAL IONIZING IRRADIATION; MYOCARDIAL-INFARCTION; BREAST-CANCER; FIBROSIS; SYSTEM; ECHOCARDIOGRAPHY; FACTOR-BETA(1); RADIOTHERAPY;

D O I：

10.3109/09553002.2010.492489

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Material and methods: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-beta 1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting. Cardiac structural and functional alterations were investigated at the four-month time point by echocardiography and by quantitative methods (stereology). Results: Rats irradiated with 15 Gy showed a modest reduction in the ejection fraction. Cardiac proc-I, TGF-beta 1, ACE and AT1 were also measurably increased. Conclusions: Irradiated rat hearts show simultaneous elevations in renin-angiotensin system components AT1 and ACE and cardiac remodeling markers proc-I and TGF-beta 1.

引用

页码：880 / 887

页数：8

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