Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats

被引：14
|
作者：
Ferreira-Machado, Samara Cristina [1 ,2 ,3 ]
Rocha, Nazareth De Novaes [5 ]
Mencalha, Andre Luiz [3 ]
Barbosa De Melo, Luiz Dione [4 ]
Salata, Camila [2 ]
Ribeiro, Andreia Fortes [2 ]
Torres, Thiago Da Silva [6 ]
Mandarim-De-Lacerda, Carlos Alberto [6 ]
Canary, Paulo Cesar [7 ]
De Freitas Peregrino, Antonio Augusto [2 ]
Goncalves Magalhaes, Luis Alexandre [2 ]
Cabral-Neto, Januario Bispo [3 ]
Dealmeida, Carlos Eduardo [2 ]
机构：
[1] Univ Fed Fluminense, Dept Biol Geral GBG, Lab Radiobiol & Radiomet, BR-24020140 Niteroi, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Dept Biofis & Biomet, Lab Ciencias Radiol, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, CCS, Lab Controle Expressao Genica, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil
[4] Univ Fed Fluminense, Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, Genet Mol Lab, BR-24020140 Niteroi, RJ, Brazil
[5] Univ Fed Fluminense, Dept Fisiol & Farmacol, BR-24020140 Niteroi, RJ, Brazil
[6] Univ Fed Rio de Janeiro, Inst Biol, Lab Morfomet & Morfol Cardiovasc, Rio De Janeiro, Brazil
[7] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Serv Radioterapia, Fac Med,Dept Radiol, BR-21941 Rio De Janeiro, Brazil
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2010年 / 86卷 / 10期
关键词：
GROWTH-FACTOR-BETA; INDUCED HEART-DISEASE; LOCAL IONIZING IRRADIATION; MYOCARDIAL-INFARCTION; BREAST-CANCER; FIBROSIS; SYSTEM; ECHOCARDIOGRAPHY; FACTOR-BETA(1); RADIOTHERAPY;
D O I：
10.3109/09553002.2010.492489
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Material and methods: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-beta 1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting. Cardiac structural and functional alterations were investigated at the four-month time point by echocardiography and by quantitative methods (stereology). Results: Rats irradiated with 15 Gy showed a modest reduction in the ejection fraction. Cardiac proc-I, TGF-beta 1, ACE and AT1 were also measurably increased. Conclusions: Irradiated rat hearts show simultaneous elevations in renin-angiotensin system components AT1 and ACE and cardiac remodeling markers proc-I and TGF-beta 1.
引用
收藏
页码：880 / 887
页数：8
相关论文
共 50 条
  • [1] Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    Ferrario, CM
    Jessup, J
    Chappell, MC
    Averill, DB
    Brosnihan, KB
    Tallant, EA
    Diz, DI
    Gallagher, PE
    CIRCULATION, 2005, 111 (20) : 2605 - 2610
  • [2] Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists
    Kyrmizakis, DE
    Papadakis, CE
    Liolios, AD
    Karatzanis, AD
    Malandrakis, S
    Skoulakis, CE
    Bizakis, JG
    Velegrakis, GA
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2004, 130 (12) : 1416 - 1419
  • [3] Inhibition of angiotensin-converting enzyme by selective stimulation of angiotensin II type 2 receptor
    Gholamreza-Fahimi, E.
    Bisha, M.
    Hansen, F. K.
    Kurz, T.
    Kojda, G.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017, 390 : S38 - S38
  • [4] Endogenous angiotensin II levels and the mechanism of action of angiotensin-converting enzyme inhibitors and angiotensin receptor type 1 antagonists
    Campbell, DJ
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1996, 23 : S125 - S131
  • [5] Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure - Role of kinins and angiotensin II type 2 receptors
    Liu, YH
    Yang, XP
    Sharov, VG
    Nass, O
    Sabbah, HN
    Peterson, E
    Carretero, OA
    JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (08): : 1926 - 1935
  • [6] Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and coronavirus
    Verdecchia, Paolo
    Angeli, Fabio
    Reboldi, Gianpaolo
    JOURNAL OF HYPERTENSION, 2020, 38 (06) : 1190 - 1191
  • [7] Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    P Dandona
    S Dhindsa
    H Ghanim
    A Chaudhuri
    Journal of Human Hypertension, 2007, 21 : 20 - 27
  • [8] Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    Dandona, P.
    Dhindsa, S.
    Ghanim, H.
    Chaudhuri, A.
    JOURNAL OF HUMAN HYPERTENSION, 2007, 21 (01) : 20 - 27
  • [9] Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers
    Sarzani, Riccardo
    Giulietti, Federico
    Di Pentima, Chiara
    Giordano, Piero
    Spannella, Francesco
    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2021, 28 (16) : E10 - E13
  • [10] Progression of aortic stenosis is slowed by angiotensin-converting enzyme inhibition but not by angiotensin II type 1 receptor blockade
    Wakabayashi, Kana
    Goda, Akiko
    Nakao, Shinji
    Otsuka, Misato
    Matsumoto, Mika
    Tsutsumi, Chikako
    Lee, Masaaki
    Tsujino, Takeshi
    Masuyama, Tohru
    CIRCULATION, 2006, 114 (18) : 657 - 657
12345