The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract

被引:520
|
作者
Derrien, Muriel [1 ]
Collado, M. Carmen [2 ,3 ]
Ben-Amor, Kaouther [1 ]
Salminen, Seppo [2 ,3 ]
de Vos, Willem M. [1 ]
机构
[1] Microbiol Lab, NL-6703 HB Wageningen, Netherlands
[2] Univ Turku, FI-20014 Turku, Finland
[3] Univ Helsinki, Dept Vet Basic Sci, FI-00014 Helsinki, Finland
关键词
D O I
10.1128/AEM.01226-07
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A 16S rRNA-targeted probe, MUC-1437, was designed and validated in order to determine the presence and numbers of cells of Akkermansia muciniphila, a mucin degrader, in the human intestinal tract. As determined by fluorescent in situ hybridization, A. muciniphild accounted more than 1% of the total fecal cells and was shown to be a common bacterial component of the human intestinal tract.
引用
收藏
页码:1646 / 1648
页数:3
相关论文
共 50 条
  • [31] Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges
    Luo, Yuheng
    Lan, Cong
    Li, Hua
    Ouyang, Qingyuan
    Kong, Fanli
    Wu, Aimin
    Ren, Zhihua
    Tian, Gang
    Cai, Jingyi
    Yu, Bing
    He, Jun
    Wright, Andre-Denis G.
    NPJ BIOFILMS AND MICROBIOMES, 2022, 8 (01)
  • [32] Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier
    Liu, Yang
    Liu, Qing
    Zhang, Chengcheng
    Zhao, Jianxin
    Zhang, Hao
    Chen, Wei
    Zhai, Qixiao
    FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (05) : 1526 - 1537
  • [33] AKKERMANSIA MUCINIPHILA AND CORRELATIONS WITH THE PERCENTAGE OF SULFATED MUCIN IN THE MUCUS GEL LAYER OF INDIVIDUALS WITH ULCERATIVE COLITIS
    Earley, H.
    Lennon, G.
    Balfe, A.
    Coffey, J. C.
    Winter, D. C.
    O'Connell, P. R.
    BRITISH JOURNAL OF SURGERY, 2019, 106 : 23 - 23
  • [34] EFFECTS OF THE NEXT GENERATION PROBIOTIC, AKKERMANSIA MUCINIPHILA, ON INTESTINAL INFLAMMATION AND BARRIER FUNCTION
    Grondin, Jensine
    Wang, Huaqing
    Haq, Sabah
    Kwon, Yun Han
    MacNeil, Lesley
    Surette, Michael
    Khan, Waliul
    GASTROENTEROLOGY, 2023, 164 (06) : S1153 - S1153
  • [35] Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila
    Becken, Bradford
    Davey, Lauren
    Middleton, Dustin R.
    Mueller, Katherine D.
    Sharma, Agastya
    Holmes, Zachary C.
    Dallow, Eric
    Remick, Brenna
    Barton, Gregory M.
    David, Lawrence A.
    McCann, Jessica R.
    Armstrong, Sarah C.
    Malkus, Per
    Valdivia, Raphael H.
    MBIO, 2021, 12 (03):
  • [36] Supplementation with Akkermansia muciniphila improved intestinal barrier and immunity in zebrafish ( Danio rerio)
    Wang, Yawei
    Huang, Zhenyi
    Gui, Zewei
    Yang, Boya
    You, Fu
    Yang, Guokun
    Zhang, Xindang
    Chang, Xulu
    Meng, Xiaolin
    FISH & SHELLFISH IMMUNOLOGY, 2024, 154
  • [37] Effects of Akkermansia muciniphila and Faecalibacterium prausnitzii on serotonin transporter expression in intestinal epithelial cells
    Rezvan Yaghoubfar
    Ava Behrouzi
    Abolfazl Fateh
    Seyed Ali Nojoumi
    Farzam Vaziri
    Shohreh Khatami
    Seyed Davar Siadat
    Journal of Diabetes & Metabolic Disorders, 2021, 20 : 1 - 5
  • [38] Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa
    de Vos, Willem M.
    MICROBIOLOGY-SGM, 2017, 163 (05): : 646 - 648
  • [39] Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases
    Liu, Meng-Jie
    Yang, Jing-Yu
    Yan, Zhen-Hua
    Hu, Shuang
    Li, Jun-Qi
    Xu, Zhi-Xiang
    Jian, Yong -Ping
    CLINICAL NUTRITION, 2022, 41 (10) : 2333 - 2344
  • [40] Dietary strategies to promote the abundance of intestinal Akkermansia muciniphila, a focus on the effect of plant extracts
    Yue, Chenbo
    Chu, Chuanqi
    Zhao, Jianxin
    Zhang, Hao
    Chen, Wei
    Zhai, Qixiao
    JOURNAL OF FUNCTIONAL FOODS, 2022, 93