Voltammetric determination of cefpirome at multiwalled carbon nanotube modified glassy carbon sensor based electrode in bulk form and pharmaceutical formulation

A new, simple and low cost voltammetric method for the determination of cefpirome in pharmaceutical preparations has been developed using multiwalled carbon nanotube modified glassy carbon electrode (MWCNT), which showed stable response with enhanced selectivity and sensitivity over the bare glassy carbon electrode. A multiwalled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) is used for the simultaneous determination of cefpirome by differential pulse voltammetry and square wave voltammetry. Results indicated that cathodic peak of cefpirome is greatly improved at MWCNT modified GC electrode as compared with the bare GC electrode showing excellent electrocatalytic activity towards cefpirome reduction. Linear calibration curves are obtained over the concentration range 100-600 mu gmL(-1) in Britton Robinson buffer at pH 4.51 with limit of detection (LOD) and limit of quantification (LOQ) are 0.647 mu gmL(-1) and 2.159 mu g mL(-1) using SWV and 5.540 mu g mL(-1) and 18.489 mu g mL(-1) using DPV, respectively. The described method is rapid and can be successfully applied for the determination of cefpirome in bulk form and pharmaceutical formulations. (C) 2011 Elsevier B.V. All rights reserved.