Expedient Cobalt-Catalyzed C-H Alkynylation of (Enantiopure) Benzylamines

被引：60

作者：

Landge, Vinod G. ^{[1
,3
]}

Midya, Siba P. ^{[1
,3
]}

Rana, Jagannath ^{[1
,3
]}

Shinde, Dinesh R. ^{[2
]}

Balaraman, Ekambaram ^{[1
,3
]}

机构：

[1] CSIR, Natl Chem Lab, Catalysis Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

[2] CSIR, Natl Chem Lab, Cent NMR Facil, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

[3] Acad Sci & Innovat Res, New Delhi 110025, India

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 20期

关键词：

TERMINAL ALKYNES; BOND ACTIVATION; DIRECTED FUNCTIONALIZATION; AMINOQUINOLINE BENZAMIDES; ORTHO-C(SP(2))-H BONDS; MECHANISTIC INSIGHTS; SELECTIVE ACCESS; CARBON-HYDROGEN; NICKEL; ANNULATION;

D O I：

10.1021/acs.orglett.6b02549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A unified strategy for cobalt-catalyzed ortho-C-H bond alkynylation of benzylamines is reported. Simple, commercially available CoBr2 was used as a cobalt source. The developed alkynylation strategy is robust and efficient and has a broad substrate scope including 1 degrees, 2 degrees, and 3 degrees benzylamines. The mechanistic study shows that C-H bond cleavage is reversible, and the kinetic study illustrates that the rate of reaction depends solely on the catalyst.

引用

页码：5252 / 5255

页数：4

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