Potent, selective MCH-1 receptor antagonists

被引：8

作者：

Erickson, Shawn D. ^{[1
]}

Banner, Bruce ^{[1
]}

Berthel, Steven ^{[1
]}

Conde-Knape, Karin ^{[2
]}

Falcioni, Fiorenza ^{[2
]}

Hakimi, Irina ^{[2
]}

Hennessy, Bernard ^{[1
]}

Kester, Robert F. ^{[1
]}

Kim, Kyungjin ^{[1
]}

Ma, Chun ^{[1
]}

McComas, Warren ^{[1
]}

Mennona, Francis ^{[1
]}

Mischke, Steven ^{[1
]}

Orzechowski, Lucy ^{[1
]}

Qian, Yimin ^{[1
]}

Salari, Hamid ^{[1
]}

Tengi, John ^{[1
]}

Thakkar, Kshitij ^{[1
]}

Taub, Rebecca ^{[2
]}

Tilley, Jefferson W. ^{[1
]}

Wang, Hong ^{[1
]}

机构：

[1] Hoffmann La Roche Inc, Discovery Chem, Nutley, NJ 07110 USA

[2] Hoffmann La Roche Inc, Dept Metab Dis, Nutley, NJ 07110 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.bmcl.2008.01.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity pro. le appropriate for in vivo efficacy studies and safety. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1402 / 1406

页数：5

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