Association of interleukin-8 (IL-8 or CXCL8)-251T/A and CXCR2+1208C/T gene polymorphisms with breast cancer

被引：0
|
作者：
Kamali-Sarvestani, E. [1 ]
Aliparasti, M. R.
Atefi, S.
机构：
[1] Shiraz Univ, Sch Med, Dept Immunol, Shiraz, Iran
[2] Shiraz Univ, Sch Med, Res Ctr, Dept Autoimmun Dis, Shiraz, Iran
[3] Shiraz Univ, Sch Med, Dept Surg, Shiraz, Iran
来源：
NEOPLASMA | 2007年 / 54卷 / 06期
关键词：
breast cancer; IL-8; CXCR2; polymorphism;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A case-control study involving 257 breast cancer patients with invasive ductal carcinoma and 233 healthy women was carried out to explore if the IL-8 -251T/A polymorphism and the CXCR2 +1208 C/T polymorphism have a role in breast cancer susceptibility. Genotypic analysis showed an increased frequency of high producer IL-8 -251 AA genotype (p=0.016) in the patient group as compared to controls while CXCR2 +1208 C/T polymorphism did not show any differences between studied groups. However, in contrast to IL-8 -251 polymorphism, the percentage of CXCR2 +1208 TT genotype was significantly lower in patients with NPI <= 3.4 compared to NPI>3.4 (2% and 12%, respectively; p=0.03). Also, ER- tumors showed an approximately significant higher CXCR2 +1208 TT genotype compared to ER+ tumors (18.6% and 7.1%, respectively; p=0.07). In conclusion, IL-8 -251T/A polymorphism is associated with development of invasive ductal carcinoma type of breast cancer while CXCR2 +1208C/T polymorphism may affect the disease progression.
引用
收藏
页码：484 / 489
页数：6
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