Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?

被引：42

作者：

Ballesteros, Alejandro ^{[1
,2
]}

Sanchez-Torres, Ana M. ^{[2
,3
]}

Lopez-Ilundain, Jose M. ^{[2
,3
]}

Cabrera, Bibiana ^{[4
,5
]}

Lobo, Antonio ^{[6
]}

Gonzalez-Pinto, Ana M. ^{[5
,7
,8
]}

Diaz-Caneja, Covadonga ^{[5
,9
]}

Corripio, Iluminada ^{[5
,10
]}

Vieta, Eduard ^{[5
,11
,12
,13
,14
]}

de la Serna, Elena ^{[5
,15
]}

Bobes, Julio ^{[5
,16
,17
]}

Usall, Judith ^{[5
,18
]}

Contreras, Fernando ^{[5
,19
,20
]}

Lorente-Omenaca, Ruth ^{[2
,3
]}

Mezquida, Gisela ^{[4
,5
]}

Bernardo, Miguel ^{[4
,5
,14
]}

Cuesta, Manuel J. ^{[2
,3
]}

机构：

[1] Estella Mental Hlth Ctr, Direcc Salud Mental, Pamplona, Navarra, Spain

[2] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[3] Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain

[4] Hosp Clin Barcelona, Neurosci Inst, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain

[5] Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain

[6] Univ Zaragoza, Aragon Inst Hlth Res IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain

[7] Univ Hosp, OSI Araba, BIOARABA Hlth Res Inst, Vitoria, Spain

[8] Univ Basque Country, Vitoria, Spain

[9] Univ Complutense, Univ Gregorio Maranon, Sch Med, Hosp Gen,IiSGM,Dept Child & Adolescent Psychiat, Madrid, Spain

[10] UAB, Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain

[11] Hosp Clin Barcelona, Clin Inst Neurosci, Dept Psychiat & Psychol, Catalonia, Spain

[12] August Pi i Sunyer Inst Biomed Res IDIBAPS, Barcelona, Catalonia, Spain

[13] Univ Barcelona, Dept Psychiat & Clin Psychol, Barcelona, Catalonia, Spain

[14] Univ Barcelona, IDIBAPS, Dept Psychiat & Clin Psychobiol, Barcelona, Spain

[15] Univ Barcelona, Hosp Clin Barcelona, Inst Clin Neurosci,Dept Med,2014SGR489, IDIBAPS,Child & Adolescent Psychiat & Psychol Dep, Barcelona, Spain

[16] Univ Oviedo, Psychiat Dept, Oviedo, Spain

[17] INEUROPA, Inst Neurosci Principal Asturias, Oviedo, Spain

[18] Parc Sanitari St Joan Deu, Barcelona, Spain

[19] Bellvitge Univ Hospital, IDIBELL, Psychiat Dept, Lhospitalet De Llobregat, Spain

[20] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain

[21] Univ Valencia, Dept Med, Valencia, Spain

来源：

PSYCHOLOGICAL MEDICINE | 2018年 / 48卷 / 13期

关键词：

Anticholinergic; antipsychotics; cognition; first episode psychosis; premorbid intellectual quotient; SYNDROME SCALE PANSS; NAIVE PATIENTS; DOUBLE-BLIND; 1ST EPISODE; NEUROPSYCHOLOGICAL PERFORMANCE; CHRONIC-SCHIZOPHRENIA; OPEN-LABEL; RISPERIDONE; OLANZAPINE; CONSENSUS;

D O I：

10.1017/S0033291717003774

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups. Methods. Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively]. Results. Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup. Conclusions. Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.

引用

页码：2247 / 2256

页数：10

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