The cerebral ventricles correspond to the intra-hemispheric (lateral) and interhemispheric cavities (III and IV) where cerebrospinal fluid is produced and circulated, they are organized in a closed and interconnected circuit, which is continuous with the subarachnoid space where it filters into the venous system through arachnoid granulations. Clinical case: 58-year-old woman was admitted to the emergency department with headache, nausea, photophobia and phonophobia that worsened in the early morning hours. Given a picture compatible with migraine headache and warning signs, it was decided to give analgesic management and imaging studies were requested, which reported and asymmetry of the lateral ventricles. It was decided to release after the control of the reason for consultation. And control by external consultation. Conclusion: Brain variants and asymmetries are generally considered incidental finding that may or may not be associated with symptoms of different degrees of severity. Knowledge of them and their possible clinical correlation is an important element for diagnosis and therapeutic conduct in general and specialized medicine.