Butyrolactones from the Fungus Aspergillus terreus BCC 4651

被引：83
|
作者：
Haritakun, Rachada [1 ]
Rachtawee, Pranee [1 ]
Chanthaket, Rungtiwa [1 ]
Boonyuen, Nattawut [1 ]
Isaka, Masahiko [1 ]
机构：
[1] Natl Ctr Genet Engn & Biotechnol, Klongluang 12120, Pathumthani, Thailand
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 11期
关键词：
Aspergillus terreus; butyrolactone; antimalarial activity; antitubercular activity; METABOLIC PRODUCTS; I DERIVATIVES; CDC2; KINASE; STRAIN; INHIBITOR;
D O I：
10.1248/cpb.58.1545
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new butenolides, butyrolactones VI (1) and VII (2), were isolated together with six known compounds, butyrolactones I (3), II (4), IV (5), and V (6), aspernolide B (7), and bisdethiodi(methylthio)acetylaranotin (8) from the fungus Aspergillus terreus BCC 4651. Compound 8, exhibiting a minimum inhibitory concentration (MIC) value of 1.56 mu g/ml against Mycobacterium tuberculosis H37Ra, proved to be the antimycobacterial principle from the culture of this fungus. On the other hand, butyrolactone V (6) showed antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 mu g/ml.
引用
收藏
页码：1545 / 1548
页数：4
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