Ruthenium(III and II) β-diketonate complexes containing imidazoles

被引：8
|
作者：
Baird, Ian R. [1 ]
Patrick, Brian O. [1 ]
Skov, Kirsten A. [2 ]
James, Brian R. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
[2] British Columbia Canc Res Ctr, Adv Therapeut, Vancouver, BC V5Z 1L3, Canada
来源：
INORGANICA CHIMICA ACTA | 2017年 / 466卷
基金：
英国医学研究理事会; 加拿大自然科学与工程研究理事会;
关键词：
Ruthenium; Acetylacetonate; Hexafluoroacetonate; Imidazoles; X-ray structures; X-RAY-STRUCTURE; ELECTROCHEMICAL PROPERTIES; CRYSTAL-STRUCTURES; REDOX POTENTIALS; SPECTRA; LIGAND; KP1019; COORDINATION; DERIVATIVES; REACTIVITY;
D O I：
10.1016/j.ica.2017.07.016
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The Ru-III complexes, [Ru(acac)(2)L-2] Tf, and the Ru-II complexes, Ru(hfac)(2)L-2, have been synthesized and characterized; acac = acetylacetonate, hfac = 1,1,1,5,5,5-hexafluoroacetonate, Tf = triflate, and L = imidazole (Im) or a substituted imidazole (NMeIm, 2MeIm, 4/5MeIm, 2NO(2)Im); other nitroimidazoles, named metronidazole, etanidazole, and EF5 (a pentafluorinated derivative of etanidazole) were also used. Cis-isomers of the Ru complexes were usually formed, but some trans-isomers were also isolated. Characterization methods include NMR, UV/Vis, and MS spectroscopies, and CV data; X-ray crystallographic data were obtained for the cis-[Ru(acac)(2)L-2] Tf complexes (L = Im, NMeIm, 2MeIm, and 5MeIm). Interest in these complexes stems from their potential antiproliferatory activity, and use of the nitroimidazole species as radiosensitizers. More incidentally synthesized were cis-[Ru(acac)(2)L(MeCN)] Tf (L = Im, 2MeIm), cis-Ru(hfac)(2)Im(MeCN), and [Ru(hfac)(NMeIm)(4)]PF6. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：565 / 577
页数：13
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