Neural mechanisms underlying the therapeutic actions of guanfacine treatment in youth with ADHD: A pilot fMRI study

被引：9

作者：

Bedard, Anne-Claude V. ^{[1
]}

Schulz, Kurt P. ^{[1
]}

Krone, Beth ^{[1
]}

Pedraza, Juan ^{[1
]}

Duhoux, Stephanie ^{[1
]}

Halperin, Jeffrey M. ^{[1
,2
]}

Newcorn, Jeffrey H. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 231卷 / 03期

关键词：

ADHD; fMRI; Guanfacine; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; MEDIAL PREFRONTAL CORTEX; METHYLPHENIDATE; VALIDITY; RELEASE;

D O I：

10.1016/j.pscychresns.2015.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twenty-five youth with attention-deficit/hyperactivity disorder (ADHD) were scanned with functional magnetic resonance imaging (fMRI) while performing a Go/No-go task before and after 6-8 weeks of randomized once-daily treatment with either the alpha(2A)-adrenergic receptor agonist guanfacine or placebo. Clinical improvement was greater for guanfacine than placebo and was differentially associated with reduced activation for guanfacine compared with placebo in the right midcingulate cortex/supplementary motor area and the left posterior cingulate cortex. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：353 / 356

页数：4

共 50 条

[21] Effects of computerized cognitive training as add-on treatment to stimulants in ADHD: a pilot fMRI study
de Oliveira Rosa, Virginia
Rosa Franco, Alexandre
Abrahao Salum Junior, Giovanni
Moreira-Maia, Carlos Renato
Wagner, Flavia
Simioni, Andre
de Fraga Bassotto, Caroline
R. Moritz, Guilherme
Schaffer Aguzzoli, Cristiano
Buchweitz, Augusto
Schmitz, Marcelo
Rubia, Katya
Paim Rohde, Luis Augusto
BRAIN IMAGING AND BEHAVIOR, 2020, 14 (05) : 1933 - 1944
[22] Effects of computerized cognitive training as add-on treatment to stimulants in ADHD: a pilot fMRI study
Virginia de Oliveira Rosa
Alexandre Rosa Franco
Giovanni Abrahão Salum Júnior
Carlos Renato Moreira-Maia
Flávia Wagner
André Simioni
Caroline de Fraga Bassotto
Guilherme R. Moritz
Cristiano Schaffer Aguzzoli
Augusto Buchweitz
Marcelo Schmitz
Katya Rubia
Luis Augusto Paim Rohde
Brain Imaging and Behavior, 2020, 14 : 1933 - 1944
[23] Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder
Strong, Caroline E.
Kabbaj, Mohamed
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2020, 14
[24] Neural mechanisms underlying suicide behavior in youth with bipolar disorder
Huber, Rebekah S.
Yurgelun-Todd, Deborah A.
BIPOLAR DISORDERS, 2020, 22 (02) : 193 - 194
[25] The Neural Selection and Integration of Actions and Objects: An fMRI Study
Yoon, Eun Young
Humphreys, Glyn W.
Kumar, Sanjay
Rotshtein, Pia
JOURNAL OF COGNITIVE NEUROSCIENCE, 2012, 24 (11) : 2268 - 2279
[26] Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders
Wulff, Andreas B.
Nichols, Charles D.
Thompson, Scott M.
NEUROPHARMACOLOGY, 2023, 231
[27] FMRI Study on the Neural Mechanisms of Sensorimotor Transformations
Saleh, Soha
Adamovich, Sergei
Grafton, Scott
Tunik, Eugene
2009 35TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE, 2009, : 346 - +
[28] Developmental Changes in Neural Mechanisms Underlying Spatial Working Memory Deficits in ADHD
Loo, Sandra K.
Lenartowicz, Agatha
Galvan, Adriana
Bookheimer, Susan
McGough, James
Bilder, Robert
McCracken, James
BIOLOGICAL PSYCHIATRY, 2013, 73 (09) : 88S - 88S
[29] StopWatch: Pilot study for an Apple Watch application for youth with ADHD
Leikauf, John E.
Correa, Carlos
Bueno, Andrew N.
Sempere, Vicente Peris
Williams, Leanne M.
DIGITAL HEALTH, 2021, 7
[30] Neural dysfunction in postpartum depression: An fMRI pilot study
Silverman, Michael E.
Loudon, Holly
Safier, Michal
Protopopescu, Xenia
Leiter, Gila
Liu, Xun
Goldstein, Martin
CNS SPECTRUMS, 2007, 12 (11) : 853 - 862

← 1 2 3 4 5 →