Neural mechanisms underlying the therapeutic actions of guanfacine treatment in youth with ADHD: A pilot fMRI study

被引：9
|
作者：
Bedard, Anne-Claude V. [1 ]
Schulz, Kurt P. [1 ]
Krone, Beth [1 ]
Pedraza, Juan [1 ]
Duhoux, Stephanie [1 ]
Halperin, Jeffrey M. [1 ,2 ]
Newcorn, Jeffrey H. [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
[2] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 231卷 / 03期
关键词：
ADHD; fMRI; Guanfacine; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; MEDIAL PREFRONTAL CORTEX; METHYLPHENIDATE; VALIDITY; RELEASE;
D O I：
10.1016/j.pscychresns.2015.01.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Twenty-five youth with attention-deficit/hyperactivity disorder (ADHD) were scanned with functional magnetic resonance imaging (fMRI) while performing a Go/No-go task before and after 6-8 weeks of randomized once-daily treatment with either the alpha(2A)-adrenergic receptor agonist guanfacine or placebo. Clinical improvement was greater for guanfacine than placebo and was differentially associated with reduced activation for guanfacine compared with placebo in the right midcingulate cortex/supplementary motor area and the left posterior cingulate cortex. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：353 / 356
页数：4
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