Development and Validation of an HPLC Method for Mefloquine Hydrochloride Determination in Tablet Dosage Form

被引：0

作者：

Andrade Nogueira, Fernando Henrique ^{[1
]}

Lana Goulart, Leticia de Paula ^{[1
]}

Cesar, Isabela da Costa ^{[1
]}

Moreira de Campos, Ligia Maria ^{[1
]}

Pianetti, Gerson Antonio ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF AOAC INTERNATIONAL | 2011年 / 94卷 / 04期

关键词：

LIQUID-CHROMATOGRAPHIC METHOD; BIOLOGICALLY-ACTIVE COMPOUNDS; INITIAL EXPERIMENTS; ANTIMALARIAL; MALARIA; PLASMA; BLOOD; ASSAY;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple HPLC method for determination of mefloquine hydrochloride in tablets was developed and validated. The separation was carried out on an Xterra RP18 (250 x 4.6 mm id, 5 pm particle size) analytical column. The mobile phase was 0.05 M monobasic potassium phosphate buffer (pH 3.5) methanol (40 + 60, v/v). The flow rate and wavelength were set to 1 mL/min and 283 nm, respectively. The method was specific for mefloquine hydrochloride in the presence of hydrolytic, oxidative, and photolytic degradation products. It was also linear, precise, accurate, and robust, being suitable for routine QC analyses and stability studies. The developed HPLC method was compared to a previously described spectrophotometric method.

引用

页码：1089 / 1093

页数：5

共 50 条

[41] Development and Validation of Stability Indicating HPLC Method for Combination Tablet Dosage Form of Efavirenz, Lamivudine and Tenofovir in Tablet
Reddiah, C. H. Venkat
Devi, P. Rama
Mukkanti, K.
Srinivasu, P.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH, 2012, 2 (01): : 40 - 45
[42] Development and validation of RP-HPLC method for determination of Atorvastatin calcium and Nicotinic acid in combined tablet dosage form
Sangshetti, Jaiprakash N.
Aqeel, Mohammed
Zaheer, Zahid
Ahmed, Rana Z.
Dehghan, M. H. G.
Gonjari, Indrajeet
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2016, 20 : S328 - S333
[43] RP-HPLC Accelerated Degradation Method Development and Validation for Determination of Amlodipine and Atorvastatin in Combination Dosage Form of Tablet
Chabukswar, Anuruddha Rajaram
Sakpal, Pramod Hindurao
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2021, 55 (02) : 598 - 606
[44] DEVELOPMENT AND VALIDATION OF A FAST AND SIMPLE RP-HPLC METHOD FOR THE DETERMINATION OF DIOSMIN AND HESPERIDIN IN COMBINED TABLET DOSAGE FORM
Piponski, Marjan
Stoimenova, Tanja Bakovska
Topkoska, Marina
Stefov, Stefan
Piponska, Magdalena
Serafimovska, Gordana Trendovska
MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING, 2018, 37 (02) : 127 - 134
[45] Development of a Stability-Indicating UPLC Method for the Determination of Metoclopramide Hydrochloride in Tablet Dosage Form
Vejendla, Ravikumar
Kudidhi, Vasavi
Sravanthi, S.
Taruni, G.
Musthafa, Md.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH, 2013, 3 (02): : 83 - 86
[46] DEVELOPMENT OF VALIDATED RP - HPLC METHOD FOR THE DETERMINATION OF ZIPRASIDONE HYDROCHLORIDE IN CAPSULE DOSAGE FORM
Chitra, B.
Ravi, T. K.
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (07): : 6778 - 6783
[47] RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE EXTENDED RELEASE TABLET DOSAGE FORM
Sreevatsav, A. Santosh Kumar
Harishbabu, A. K.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (11): : 4477 - 4487
[48] DEVELOPMENT AND VALIDATION OF A RAPID RP-HPLC METHOD FOR ESTIMATION OF SPARFLOXACIN IN TABLET DOSAGE FORM
Bera, Ashok Kumar
Kumar, De Amit
Pal, Biswajit
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (02): : 563 - 567
[49] METHOD DEVELOPMENT AND VALIDATION OF ZOPICLONE IN BULK AND TABLET DOSAGE FORM USING RP-HPLC
Chopra, I.
Kaur, J.
Yadav, D. K.
Hasan, M.
Tyagi, P. K.
Kumar, B.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (07): : 2876 - 2881
[50] Development and Validation of a New Spectrophotometric Method for the Determination of Regorafenib in Pure and Tablet Dosage Form
Albayrak, Mevlut
LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (07): : 1349 - 1353

← 1 2 3 4 5 →