Fetal programming of the metabolic syndrome

被引:112
|
作者
Marciniak, Aleksandra [1 ]
Patro-Malysza, Jolanta [1 ]
Kimber-Trojnar, Zaneta [1 ]
Marciniak, Beata [1 ]
Oleszczuk, Jan [1 ]
Leszczynska-Gorzelak, Boena [1 ]
机构
[1] Med Univ Lublin, Dept Obstet & Perinatol, Jaczewskiego 8, PL-20954 Lublin, Poland
来源
关键词
fetal development; genetic predisposition to disease; metabolic syndrome X; nutritional status; pregnancy; LOW-BIRTH-WEIGHT; INSULIN-RESISTANCE; DIABETES-MELLITUS; POSTNATAL-GROWTH; MATERNAL OBESITY; FAMINE EXPOSURE; RESTRICTION; EXPRESSION; METHYLATION; DIET;
D O I
10.1016/j.tjog.2017.01.001
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Prenatal development is currently recognized as a critical period in the etiology of human diseases. This is particularly so when an unfavorable environment interacts with a genetic predisposition. The fetal programming concept suggests that maternal nutritional imbalance and metabolic disturbances may have a persistent and intergenerational effect on the health of offspring and on the risk of diseases such as obesity, diabetes, and cardiovascular diseases. (C) 2017 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
引用
收藏
页码:133 / 138
页数:6
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