The dissociation constants of 1,1′-bis (pyridinium-4-aldoxime)trimethylene dibromide

被引：7
|
作者：
Foretic, B [1 ]
Burger, N [1 ]
机构：
[1] Univ Zagreb, Fac Med, Dept Chem & Biochem, Zagreb 10000, Croatia
来源：
MONATSHEFTE FUR CHEMIE | 2004年 / 135卷 / 03期
关键词：
1,1 '-bis(pyridinium-4-aldoxime) trimethylene dibromide; dissociation constants; spectrophotometry;
D O I：
10.1007/s00706-003-0116-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The dissociation constants of the two oxime groups of 1,1'-bis(pyridinium-4-aldoxime)trimethylene dibromide (TMB-4) were determined using spectrophotometric data. Two numerical methods were applied to treat the overlapping equilibria. The results obtained by both agreed with each other and their mean values at 25degreesC corrected for the ionic strength of 0.05 mol dm(-3) are pK(a1) = 7.49 +/- 0.11 and pK(a2) = 8.96 +/- 0.09. These values were discussed in terms of the pK(a)s of 1,1'-bis(pyridinium-4-aldoxime)oxydimethylene dichloride (Toxogonin), a similar dioxime, which were derived by extrapolation of literature data.
引用
收藏
页码：261 / 267
页数：7
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