Organo-catalyzed highly diastereo- and enantio-selective direct aldol reactions in water

被引：72

作者：

Zhao, Jun-Feng ^{[1
,2
,3
]}

He, Long ^{[4
,5
]}

Jiang, Jun ^{[1
,2
,3
]}

Tang, Zhuo ^{[1
,2
,3
]}

Cun, Lin-Feng ^{[1
,2
,3
]}

Gong, Liu-Zhu ^{[1
,2
,3
,4
,5
]}

机构：

[1] Chinese Acad Sci, Key Lab Asymmetr Synthesis & Chirotechnol Sichuan, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Union Lab Asymmetr Synthesis, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

[4] Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

[5] Dept Chem Sci & Technol China, Hefei 230026, Peoples R China

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 21期

基金：

中国国家自然科学基金;

关键词：

water; organocatalysis; direct aldol; diastereo- and enantio-selective;

D O I：

10.1016/j.tetlet.2008.03.131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric direct aldol reactions of a wide scope of aromatic aldehydes, with unmodified ketones in the presence of 1 mol % of organocatalyst prepared from (2R,3R)-diethyl 2-amino-3-hydroxysuccinate and trans-4-hydroxy-L-proline, were performed in water, affording aldol products in high yields with excellent diastereoselectivities of up to >99:1 and enantioselectivities of up to 98%. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3372 / 3375

页数：4

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